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chicken pizzaiola in plastic container topped with white beans

Chicken Pizzaiola over Spaghetti Squash

This Chicken Pizzaiola recipe has chicken slow cooked with marinara and wine over healthy spaghetti squash. Perfect for make-ahead lunches, this is a meal prep chicken recipe for healthy eating during your busy week.
5 from 1 vote
Prep Time 20 minutes
Cook Time 4 hours
Total Time 4 hours 20 minutes
Course Lunch, Main Course
Cuisine Italian-inspired
Servings 5 servings
Calories 381 kcal


For the chicken pizzaiola

  • 4 boneless chicken breasts
  • ½ tsp kosher salt
  • ½ tsp garlic powder
  • ½ tsp dried minced onion
  • pinch fresh cracked pepper
  • 1 cup Marinara sauce homemade or store-bought
  • ¼ cup Cabernet red wine

For the spaghetti squash

  • 3 lb spaghetti squash
  • 1 Tbsp extra virgin olive oil

For the meals

  • ½ cup Great Northern beans rinsed and drained
  • 5 tsp freshly grated parmesan cheese
  • ¼ cup chopped fresh basil leaves


Make the chicken

  • Put the chicken pizzaiola ingredients in a slow cooker, sprinkling the seasonings over the chicken before adding the marinara and wine.
  • Cook on high 4 hours or low 6 hours. Shred meat.

Roast the squash

  • Cut the spaghetti squash in half lengthwise. Scrape out the seeds.
  • Brush the flesh with olive oil and place cut side down on rimmed bake sheet. Prick skin all over with a fork.
  • Roast squash at 400°F for 40 minutes.
  • Once cool enough to handle, use a fork to fluff and shred the squash into spaghetti-like strands.

Assemble the meals

  • In each of 5 meal prep containers, layer squash, chicken, beans, parmesan, and basil.
  • Refrigerate until time to eat, then microwave 1-2 minutes to heat up.


Note that it you feel your chicken is a little dry (this is lean chicken breast after all), add a couple additional tablespoons marinara when you assemble your meals.
If using my homemade marinara sauce, omit the wine here because my recipe includes it already.


Calories: 381kcal (19%) | Carbohydrates: 27g (9%) | Protein: 43g (86%) | Fat: 5g (8%) | Saturated Fat: 1g (6%) | Polyunsaturated Fat: 1g | Cholesterol: 113mg (38%) | Sodium: 544mg (24%) | Potassium: 392mg (11%) | Fiber: 6g (25%) | Sugar: 10g (11%)

Calorie count is purely an estimate calculated using an online application to serve as a guide and not to be taken as accurate nutritional information. Percent Daily Values are based on a 2,000 calorie diet.

Keyword chicken pizzaiola, meal prep chicken
Tried this recipe?Leave a comment below and let me know!